Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans
Identifieur interne : 003E10 ( Main/Exploration ); précédent : 003E09; suivant : 003E11Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans
Auteurs : David J. Martens [Canada] ; Ian Q. Whishaw [Canada] ; Elena I. Miklyaeva [Canada] ; Sergio M. Pellis [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1996.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animal model, Animals, Apraxia, Apraxias (physiopathology), Axial apraxia, Body, Body movement, Body-on-body righting, Disease Models, Animal, Dopamine, Dopamine (physiology), Female, Hemiparkinson's disease model, Hindlimb, Humans, Limb, Motility disorder, Motor Activity, Movement, Oxidopamine, Parkinson Disease (physiopathology), Parkinson disease, Posture, Rat, Rats, Reference Values, Rotation, Substantia Nigra (pathology), Substantia Nigra (physiology), Substantia Nigra (physiopathology), Time Factors, Touch, Videotape Recording.
- MESH :
- chemical , physiology : Dopamine.
- pathology : Substantia Nigra.
- physiology : Substantia Nigra.
- physiopathology : Apraxias, Parkinson Disease, Substantia Nigra.
- Animals, Disease Models, Animal, Female, Hindlimb, Humans, Motor Activity, Movement, Oxidopamine, Posture, Rats, Reference Values, Rotation, Time Factors, Touch, Videotape Recording.
Abstract
Humans with Parkinson's disease (PD) often have problems in righting themselves, in that they have difficulty in recruiting their axial musculature to rotate the body to prone. Since this ‘axial apraxia’ is not ameliorated by l-DOPA therapy, it has been concluded that dopamine (DA) does not play a role in recruiting axial rotation of the body [14]. This hypothesis was tested by comparing the righting of rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra (SN) with that of intact rats. Body-on-body righting, where asymmetrical tactile stimulation of the body initiates hindquarter righting, was used to specifically test tactile righting independently of righting triggered or influenced by other sensory systems. In this behavioral test, rats are placed on their sides, their forequarters are held down and their hindquarters released. The DA-depleted rats took longer to begin righting, to complete righting, and used more limb action to right themselves than did control rats. These findings suggest that for this tactile based form of righting, DA-depletion produces axial apraxia. However, frame-by-frame analysis of righting sequences of DA-depleted rats showed that pelvis-led axial rotation could occur, but the spatio-temporal relationship between body and limb movements was disorganized. Therefore, following DA-depletion axial apraxia-like deficits appear to arise from sensorimotor disruption. This raises the issue of whether the axial apraxia in PD patients arises from damage to systems beyond the nigrostriatal DA system, or from interference with sensorimotor integration that is not ameliorated by replacement therapy.
Url:
DOI: 10.1016/0006-8993(96)00547-1
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000979
- to stream Istex, to step Curation: 000979
- to stream Istex, to step Checkpoint: 001820
- to stream Main, to step Merge: 004500
- to stream PascalFrancis, to step Corpus: 000F22
- to stream PascalFrancis, to step Curation: 001001
- to stream PascalFrancis, to step Checkpoint: 000E10
- to stream Main, to step Merge: 004576
- to stream PubMed, to step Corpus: 001863
- to stream PubMed, to step Curation: 001863
- to stream PubMed, to step Checkpoint: 001863
- to stream Ncbi, to step Merge: 002557
- to stream Ncbi, to step Curation: 002557
- to stream Ncbi, to step Checkpoint: 002557
- to stream Main, to step Merge: 004346
- to stream Main, to step Curation: 003E10
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans</title><author><name sortKey="Martens, David J" sort="Martens, David J" uniqKey="Martens D" first="David J." last="Martens">David J. Martens</name></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></author><author><name sortKey="Miklyaeva, Elena I" sort="Miklyaeva, Elena I" uniqKey="Miklyaeva E" first="Elena I." last="Miklyaeva">Elena I. Miklyaeva</name></author><author><name sortKey="Pellis, Sergio M" sort="Pellis, Sergio M" uniqKey="Pellis S" first="Sergio M." last="Pellis">Sergio M. Pellis</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9921736239769D767193A97AA1D997C7B1F55F51</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0006-8993(96)00547-1</idno><idno type="url">https://api-v5.istex.fr/document/9921736239769D767193A97AA1D997C7B1F55F51/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000979</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000979</idno><idno type="wicri:Area/Istex/Curation">000979</idno><idno type="wicri:Area/Istex/Checkpoint">001820</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001820</idno><idno type="wicri:doubleKey">0006-8993:1996:Martens D:spatio:temporal:impairments</idno><idno type="wicri:Area/Main/Merge">004500</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:96-0445775</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F22</idno><idno type="wicri:Area/PascalFrancis/Curation">001001</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E10</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E10</idno><idno type="wicri:doubleKey">0006-8993:1996:Martens D:spatio:temporal:impairments</idno><idno type="wicri:Area/Main/Merge">004576</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:8891308</idno><idno type="wicri:Area/PubMed/Corpus">001863</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001863</idno><idno type="wicri:Area/PubMed/Curation">001863</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001863</idno><idno type="wicri:Area/PubMed/Checkpoint">001863</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001863</idno><idno type="wicri:Area/Ncbi/Merge">002557</idno><idno type="wicri:Area/Ncbi/Curation">002557</idno><idno type="wicri:Area/Ncbi/Checkpoint">002557</idno><idno type="wicri:doubleKey">0006-8993:1996:Martens D:spatio:temporal:impairments</idno><idno type="wicri:Area/Main/Merge">004346</idno><idno type="wicri:Area/Main/Curation">003E10</idno><idno type="wicri:Area/Main/Exploration">003E10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans</title><author><name sortKey="Martens, David J" sort="Martens, David J" uniqKey="Martens D" first="David J." last="Martens">David J. Martens</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4</wicri:regionArea><wicri:noRegion>Alberta T1K 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4</wicri:regionArea><wicri:noRegion>Alberta T1K 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Miklyaeva, Elena I" sort="Miklyaeva, Elena I" uniqKey="Miklyaeva E" first="Elena I." last="Miklyaeva">Elena I. Miklyaeva</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4</wicri:regionArea><wicri:noRegion>Alberta T1K 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Pellis, Sergio M" sort="Pellis, Sergio M" uniqKey="Pellis S" first="Sergio M." last="Pellis">Sergio M. Pellis</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4</wicri:regionArea><wicri:noRegion>Alberta T1K 3M4</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">733</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="253">253</biblScope><biblScope unit="page" to="262">262</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Animals</term><term>Apraxia</term><term>Apraxias (physiopathology)</term><term>Axial apraxia</term><term>Body</term><term>Body movement</term><term>Body-on-body righting</term><term>Disease Models, Animal</term><term>Dopamine</term><term>Dopamine (physiology)</term><term>Female</term><term>Hemiparkinson's disease model</term><term>Hindlimb</term><term>Humans</term><term>Limb</term><term>Motility disorder</term><term>Motor Activity</term><term>Movement</term><term>Oxidopamine</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Posture</term><term>Rat</term><term>Rats</term><term>Reference Values</term><term>Rotation</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (physiology)</term><term>Substantia Nigra (physiopathology)</term><term>Time Factors</term><term>Touch</term><term>Videotape Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Apraxias</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Hindlimb</term><term>Humans</term><term>Motor Activity</term><term>Movement</term><term>Oxidopamine</term><term>Posture</term><term>Rats</term><term>Reference Values</term><term>Rotation</term><term>Time Factors</term><term>Touch</term><term>Videotape Recording</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Apraxie</term><term>Corps</term><term>Dopamine</term><term>Membre</term><term>Modèle animal</term><term>Mouvement corporel</term><term>Parkinson maladie</term><term>Rat</term><term>Trouble motricité</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humans with Parkinson's disease (PD) often have problems in righting themselves, in that they have difficulty in recruiting their axial musculature to rotate the body to prone. Since this ‘axial apraxia’ is not ameliorated by l-DOPA therapy, it has been concluded that dopamine (DA) does not play a role in recruiting axial rotation of the body [14]. This hypothesis was tested by comparing the righting of rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra (SN) with that of intact rats. Body-on-body righting, where asymmetrical tactile stimulation of the body initiates hindquarter righting, was used to specifically test tactile righting independently of righting triggered or influenced by other sensory systems. In this behavioral test, rats are placed on their sides, their forequarters are held down and their hindquarters released. The DA-depleted rats took longer to begin righting, to complete righting, and used more limb action to right themselves than did control rats. These findings suggest that for this tactile based form of righting, DA-depletion produces axial apraxia. However, frame-by-frame analysis of righting sequences of DA-depleted rats showed that pelvis-led axial rotation could occur, but the spatio-temporal relationship between body and limb movements was disorganized. Therefore, following DA-depletion axial apraxia-like deficits appear to arise from sensorimotor disruption. This raises the issue of whether the axial apraxia in PD patients arises from damage to systems beyond the nigrostriatal DA system, or from interference with sensorimotor integration that is not ameliorated by replacement therapy.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Martens, David J" sort="Martens, David J" uniqKey="Martens D" first="David J." last="Martens">David J. Martens</name></noRegion><name sortKey="Miklyaeva, Elena I" sort="Miklyaeva, Elena I" uniqKey="Miklyaeva E" first="Elena I." last="Miklyaeva">Elena I. Miklyaeva</name><name sortKey="Pellis, Sergio M" sort="Pellis, Sergio M" uniqKey="Pellis S" first="Sergio M." last="Pellis">Sergio M. Pellis</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003E10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9921736239769D767193A97AA1D997C7B1F55F51
|texte= Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans
}}
| This area was generated with Dilib version V0.6.29. |  |